The Al Batran laboratory was founded in 2020 by Dr. Rami Al Batran at the "Faculté de Pharmacie de l'Université de Montréal". The regulation of energy metabolism has had a resurgence of interest in the last decade (likely due to the obesity epidemic) and this field of investigation is now at the forefront of modern research topics. Thus, our research goals are to determine whether modifying energy metabolism is a druggable target for the treatment of obesity-related diseases such as type 2 diabetes and cardiovascular disease. Our lab uses experimental models of obesity to identify key genes/proteins that become altered during obesity, and utilizes mouse genetics techniques and pharmacological tools to modify these genes and alleviate the numerous adverse consequences of obesity.
Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation
Perturbations in carbohydrate, lipid, and protein metabolism contribute to obesity-induced type 2 diabetes (T2D), though whether alterations in ketone body metabolism influence T2D pathology is unknown. We report here that activity of the rate-limiting enzyme for ketone body oxidation, succinyl-CoA:3-ketoacid-CoA transferase (SCOT/Oxct1), is increased in muscles of obese mice...